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CBD Side Effects, Safety & Drug Interactions: What You Need to Know (2025 Update)

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Introduction

CBD is everywhere now. Oils, gummies, even lotions. A lot of people swear by it for sleep or stress, but others are more cautious. And honestly, that makes sense. When something suddenly becomes this popular, you want to know if it is safe.

I remember talking to a friend who tried CBD gummies to help with sleep. She said they worked, but the next morning she felt groggy, almost like a hangover without drinking. Another friend said CBD oil eased his back pain but gave him a weird dry mouth. Stories like these show that experiences are mixed.

Government groups like the FDA and CDC are trying to sort through all of this. What they say is worth paying attention to. That is what I dug into for this update.

If you ever want to try safe, tested options, Mary Jane’s Bakery Co has a variety of CBD products.

Regulatory & Official Context

If you check the FDA: What to Know About Cannabis & CBD page, you will see that only one CBD medicine is FDA approved. It is called Epidiolex and it is for rare seizure conditions. That is it. The rest of the oils and gummies you see are not officially approved.

The FDA: Cannabis & CBD Regulatory Overview explains that the big unknowns are still being studied. Things like liver safety, fertility effects, and how consistent products really are.

One person I know bought CBD oil online and it barely seemed to do anything. Later, she learned from reviews that the brand was under-dosing. That kind of thing is exactly what the FDA quality guidance warns about. Labels are not always accurate.

Common Side Effects of CBD

From what people share and what studies show, CBD can bring on some side effects. The review Cannabidiol Adverse Effects and Toxicity lists the usual ones.

  • Dry mouth. A friend of mine always keeps water nearby when she takes CBD at night.

  • Drowsiness and fatigue. Some people sleep better, others just feel sluggish the next day.

  • Stomach issues. I heard from someone who tried CBD capsules and they gave her diarrhea.

  • Feeling dizzy or lightheaded. Not super common but happens.

  • Appetite shifts. One person told me CBD made him snack more, another said it made him less hungry.

None of these are usually dangerous, but they can be annoying. If you are trying CBD for the first time, it helps to take it when you do not have anything big planned the next day. That way you see how your body reacts.

Serious Concerns, Warnings & FDA Advisories

Side effects are one thing, but the FDA has bigger warnings.

The FDA says not to use CBD if pregnant or breastfeeding. Even if the research is not complete, the risks to babies and developing brains are enough for them to say no.

There are also warnings about liver damage if you take a lot of CBD. I read about someone who added CBD oil to her daily routine and then noticed her liver enzymes were higher at her next doctor’s visit. Her doctor asked her to stop and retest. That is a good reminder to check in with your doctor if you use CBD often.

The CDC: About CBD also points out the contamination issue. A buddy of mine once ordered CBD gummies online and swore they felt “stronger than CBD.” Turns out the brand was adding THC even though the label said otherwise.

Drug Interactions & Mechanisms

Here is where CBD gets tricky. It can interact with medicines in ways most people do not expect.

CBD is broken down in the liver by the CYP450 enzyme system. A lot of medications use that same pathway. According to Cannabidiol Interactions with Medications, CBD can slow things down, which means the other drug stays in your body longer.

Some examples:

  • Blood thinners like warfarin. Too much in your system could mean unexpected bleeding.

  • Seizure drugs like clobazam. CBD can make the medicine stronger, which is not always good.

  • Antidepressants. I heard of someone who added CBD oil while on an SSRI and said their mood felt off until they stopped.

  • Immunosuppressants. These can pile up in the system, which is risky if your immune system is already weakened.

Doctors and pharmacists usually say, if you are on any prescription, talk to them before you try CBD. It is better to ask than to find out the hard way.

Dosing & Safety Guidelines

CBD dosing feels like trial and error for most people. The best tip is what a lot of folks say: start low and increase slowly.

I have a cousin who tried a full CBD gummy on her first try and said it knocked her out. Later she found that half a gummy was enough. That is how most people figure it out.

Your body weight, age, and liver health make a difference too. Older adults or people with liver issues should be especially cautious.

If you are experimenting, CBD Oil & Tinctures let you adjust your dose drop by drop. CBD Edibles & Gummies are easier to take but less flexible.

Quality Control, Testing & Safe Brands

This part matters as much as the dosing. Quality is uneven. The FDA has warned brands for lying about their CBD content or sneaking in things like delta 8 THC.

One easy tip: check for third party lab results. They are usually called COAs. A good brand will show you proof that their CBD has the right amount and does not have junk like pesticides or heavy metals.

I once bought CBD from a gas station while traveling. No lab report, no clear label. It tasted strange and I never finished the bottle. Lesson learned. Now I stick with companies that post lab reports openly.

Mary Jane’s Bakery Co does share lab testing for their products, so you know what you are actually getting. Their homepage lists what they have.

FAQ

Does CBD show up on a drug test?
Pure CBD should not, but some products sneak in THC. That is why the CDC says to be careful.

Is CBD safe with my antidepressant?
Maybe not. CBD can change how antidepressants are processed. See Cannabidiol Interactions with Medications. Best to ask your doctor.

Can I use CBD if pregnant?
The FDA says no. Even if it seems harmless, the risks are not worth it.

What are the most common CBD adverse effects?
Dry mouth, fatigue, stomach upset, and drowsiness are what most people mention.

Conclusion & CTA

CBD is interesting. It can help some people feel calmer or sleep better, but it is not without side effects or risks. Some folks only notice dry mouth. Others run into bigger issues like medication conflicts or stomach trouble. It is really about how your body handles it and which product you choose.

If you decide to try it, make sure it is from a brand that tests their products and shows you the results. That way at least you know what is in the bottle. You can look through different oils, tinctures, and edibles at Mary Jane’s Bakery Co.

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